A guide to reproducibility for funders of scientific research
In 2005, Stanford Professor John Ioannidis published his seminal paper “Why Most Published Research Findings are False,” a compelling analysis of how current scientific practice results in findings that are more likely to be false than true. This replication crisis, as it is called, comes at a significant cost - contributing to the estimated $200 billion of wasted R&D dollars every year in biomedical research alone (Pain 2014). Read More.
Grant ROI Maximization Model
A model of grant ROI in relation to the sample sizes and bias-reduction enabled by the funds provided.
Dynamically Regulated taRNA Platform
Given the exercise to design an improvement applicable to all mRNA therapeutics, this was my proposal (note: synbio is not my background, so I was coming into this naively!)
Publications
Hey, S.P., Dellapina, M., Lindquist, K. et al. Digital Health Technologies in Clinical Trials: An Ontology-Driven Analysis to Inform Digital Sustainability Policies. Ther Innov Regul Sci 57, 1269–1278 (2023). https://doi.org/10.1007/s43441-023-00560-y
Sugarman A, Vittitow A, Cheng A, Malone M, McDonald R, Pace N, Williams O, Tofighi B, McNeely J, Schatz D, Roberts T, Hey SP, Garrity K, Lindquist K, Lee JD. Opioid Use Disorder Treatments: An Evidence Map. Drug Alcohol Depend. 2022 Dec 1;241:109657. doi: 10.1016/j.drugalcdep.2022.109657. Epub 2022 Oct 14. PMID: 36332588.